The main determinant of the severity of β-thalassemia is the degree of globin chain imbalance. Coinheritance of α-thalassaemia ameliorate the clinical presentation.This study included 22 patients. (10 males and 22 females). They were diagnosed on clinical basis as β-thalassaemia intermedia patients.They were screened for the 7 common Mediterranean The most significant findings were that the mild β-mutation IVS-1-6 was found to be the commonest (22.72%),the next was IVS1-110,it was found to be (18.18%) ,the other mutations were not detected. The co-inheritance of α-thalassemia was 5/22. We recommend identification of genetic pattern for patient with thalasseamia intermedia as it is essential for genetic counseling and prenatal diagnosis.