Since the pioneering work of Marschall Warren in the early 1980, there has been extensive research around the world in to the bacterium Helicobacter pylori. Helicobacter pylori is a curved or S shaped gram negative non capsulated, non spore forming bacillus with a length of about 3um and a width of 0.5um. Helicobacter pylori is one of the most common chronic infections known and has a worldwide distribution in normal population. Recent studies reported the association between chronic infections like, H. pylori, C. pneumoniae, cytomegalovirus and ischaemic heart disease. Chronic infections causes increased fibrinogen level, leucocytes, C-reactive proteins, lipid peroxides which are risk factors for ischaemic heart disease. H. pylori causes hyperhomocysteinaemia which is a risk factor for ischaemic heart disease. H. pylori contain HSP60- like subunits which trigger atherogenesis.