Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease of connective tissue involving multiple organs. It is currently accepted that there are several genetic, environmental, and hormonal factors responsible for complex immunological disorders contributing to its development. Indeed, SLE is characterized by an orchestrated interplay amongst different types of immunopathologically important cells participating in both innate and adaptive immunity. The innate immune system has an important role in the pathogenesis of SLE. Toll-like receptors (TLRs) are a key link between infection, injury and inflammation. They recognize pathogen and danger-associated molecular patterns (PAMPs and DAMPs), and subsequently trigger a pro-inflammatory cascade. Aim of work: The aim of this work is to measure surface expression of TLR-2 and TLR-4 on CD14+ monocytes in patients with SLE and compare it with normal controls. Also to find out relation between surface expression of TLR-2, TLR-4 on CD14+ monocytes of SLE patients and disease activity according to activity scoring index (SLEDI). Results: This study revealed a significant increase of TLR-2 surface expression and a significant decrease of TLR-4 surface expression on CD14+ monocytes in SLE patients than in control group. Also, no statistically significant associations were detected with SLEDI scoring index, but only TLR-4 was negatively correlated with SLICC diagnostic criteria scoring system.