Background: Warts are benign lesions caused by human papilloma virus (HPV). Host defense against HPV relies on intact and functioning cellular immunity including T cell and natural killer (NK) cell cytotoxicity. Therefore, in patients in whom warts are severe or recalcitrant, concern for immune defects is raised. LIGHT (LT-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) signaling is important for cell survival, inflammation, and tumor eradication. Based on previous studies suggesting a role of LIGHT in control of intracellular infections as M. tuberculosis infection, we hypothesize that LIGHT may contribute to control of HPV infection. Aim of work: To identify the role of cell-mediated immunity, expressed as LIGHT level, in cases of multiple/recurrent verrucae, and to assess whether the immune response is decreased at local level in the skin only, or whether a systemic diminution in cell-mediated immunity is associated in such cases. Patients and methods: Twenty two patients presenting with multiple or recurrent warts and 21 healthy subjects, age and sex matched were included in the study. Serum and tissue LIGHT were measured for all patients and controls. All samples were examined in one sitting for LIGHT level using ELISA technique. Results: Serum and tissue LIGHT in patients with multiple or recurrent verruca vulgaris were found to be higher, but in a statistically non-significant value. Serum LIGHT level showed a highly significant inverse correlation with number of warts among patient group. Conclusion and recommendations: Patients with persistent verrucae vulgaris tend to have serum and tissue LIGHT levels comparable to those of healthy control population, explaining their inability to eradicate or control the infection. Whereas patients exhibiting positive response to therapy have higher tissue LIGHT levels and patients with higher serum LIGHT levels have less number of verrucae vulgaris. Thus, LIGHT is a limiting factor for spread of infection and it induces a positive cellular immune response against cutaneous HPV infection.