Background: Egypt has the highest prevalence of HCV worldwide 13.8 % .The only effective treatment is interferon alpha (IFN-α). As these therapies have side effects and high cost, it is important to identify patients having the best chance to respond before initiation of therapy. The monitoring of Rapid virological response (RVR) is therefore an important tool for quick identifying non-responders, permitting therapy discontinuation and avoiding adverse effects and costs.Objective: Determine a simple, easy to apply and reliable test for prediction of HCV treatment response among Egyptian patients with chronic HCV infection.Methods: This study included 21non cirrhotic non diabetics patients with chronic HCV After calculation of insulin resistance using Homeostatic model assessment (HOMA score), patients will be grouped into two groups group A with IR included (10 patients) & group B without IR included (11 patients).Data will be statistically analyzed in order to study the correlation between IR and RVR.Results:pretreatment ALT, HOMA-IR were significantly associated with RVR (P value were 0, 00072 &< 0,001) respectively on the other hand viral load (P = 0.205409), BMI (P = 0.081096), Age (P =0.690857) were not a predictor of RVR.Conclusion: Our data suggests that insulin resistance is strongly associated with RVR, thus reflecting the important role played by metabolic factors in the early phase of viral kinetics. HOMA-IR would appear to be a useful tool in predicting RVR and should be evaluated at baseline in all chronic hepatitis C patients before initiating antiviral treatment