The simplest definition of patient safety is the prevention of errors and adverse effects to patients associated with health care. While, health care has become more effective it has alsobecome more complex, with greater use of new technologies, medicines and treatments.Health services treat older and sicker patients who often present with significant comorbiditiesrequiring more and more difficult decisions as to health care priorities. Increasingeconomic pressure on health systems often leads to overloaded health care environments(WHO, 2010).Aim of the study: The present study aimed to create a patient safety friendly hospitalenvironment that helps reducing safety problems with all its consequences for the sake ofpatients and health team as well.Study methodology: The study was an intervention study conducted in the Obstetrics andGynecology hospital - Cairo University- in patient wards. It passed through three stages;baseline assessment for the hospital situation regarding patient safety, intervention stage inwhich discussion of the points needed to be improved with the hospital manager and adoptingimprovement strategies for infection control being one of the patient safety sub domains, then re evaluation to assess the changes happened after implementation of the intervention.The most important results revealed that:A. The obstetrics and gynecology hospital-Cairo University lack the compulsorystandards for patient safety especially in the leadership and management as well assafe evidence based clinical practices domains.B. Results highlight that safety culture is yet to be fully developed, as there are severalareas for improvement including error reporting, response to errors, communication,leadership and teamwork across hospital units.C. Nurses’ knowledge about hand hygiene and patient safety as well as hand hygieneperformance as a skill improved after training and promotion at the point of carelevel, while adherence showed slight improvement.The most important recommendations were:1. In order to promote patient safety practices among Cairo University Hospitals’personnel, Patient safety should be a top strategic priority for policy makers,managers, leaders and frontline staff.2. Institutional support, continuous monitoring , performance indicators calculation aswell as communication of the feedback to all staff members about hand hygieneperformance is beneficial beside increase in supplies necessary for hand hygiene.