Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), which results in a chronic focal inflammatory response with subsequent demyelination and axonal loss. It usually begins with acute episodes of neurological dysfunction, the relapses followed by periods of partial or complete remission. This relapsing-remitting phase is usually followed by a steady, continuous and irreversible worsening of the neurological dysfunction, which characterizes the progressive phase of the disease. Neurological manifestations includes; motor, sensory cerebeller, cranial nerves, brain stem and autonomic dysfunction. Changes in mood are the most disabling and distressing symptoms for individuals diagnosed with MS, yet, patients and their families receive little understanding or help with this problem.