Background: Vestibular evoked myogenic potential (VEMP) is an otolith-mediated, short-latency reflex recorded from the sternocleidomostoid muscle in response to intense auditory clicks used for evaluation of the vestibulo-spinal pathway. Objective: This study aims at: 1) Standardize VEMPs technique in Kasr El-Aini hospital. 2) Shed light on possible VEMPs affection in patients suffering from multiple sclerosis (MS). 3) Compare these findings with clinical data, other neurophysiological tests and radiological data. Methods: VEMPs were recorded from 25 MS patients (12 males and 13 females). Clinical data were evaluated for possible brain stem affection, their EDSS scores ranged from 2 to 9. All patients underwent visual evoked potential (VEP), brainstem auditory evoked potential (BAEP), somatosensory evoked potential (SSEP) studies and magnetic resonance imaging (MRI). VEMPs were also recorded in 25 age and sex matched control.Results: We found that the absolute values of the amplitude of the VEMPs response cannot be considered a reliable parameter for detecting abnormalities however the latencies of the P13 and N23 waves are more stable and best suited to reflect vestibulo-spinal system pathways integrity. VEMPs were abnormal in 56% of Patients, VEP in 56%, BAEPs in 44%, SSEPs in 28% and MRI in 80%. We also found that although MRI showed better sensitivity in detecting brain stem plaques yet 100% of patients with normal MRI had abnormal VEMPs and that BAEPs and VEMPs have nearly equal sensitivity in detecting B.S. plaques in symptomatizing group, however VEMPs were more sensitive than BAEPs in non symptomatizing group. Also we found no significant correlation between VEMPs and MRI or BAEPs. From the above mentioned findings we can see that VEMPs can be considered a complementary tool for assessing B.S. function in MS patients.Conclusion: VEMPs is a simple, non-invasive, safe and quick method, which should be considered as a complementary neurophysiological tool for evaluation of possible brain stem dysfunction.