Tissue factor (TF) is the cellular receptor and cofactor for factor VII and VIIa. TF expression can be induced on blood monocytes & vascular endothelial cells by bacterial products, inflammatory cytokines.The factor VIIa/TF complex is thought to be the major physiologic initiator of blood coagulation. In our study, monocytes expressing tissue factor of the septicemic patients was higher than the monocytes expressing tissue factor of the control group. Also monocytes expressing tissue factor was a good predictor of neonatal sepsis with the highest sensitivity and overall accuracy of the all used tests. But the combination between various tests improves the interpretation of the results.