Chronic lymphocytic leukemia (CLL) is accumulative disease which occur due to defect in programmed cell death (Apoptosis).CLL .characterized by accumulation of lymphocytes in peripheral blood, Lymph node, spleen, liver and bone marrow.Apoptosis is an evolutionarily conserved “suicide’ program present in all metazoan cells. It can be triggered by all anti-cancer drugs, irradiation, activation of cell surface death receptors and lack of growth factors.Apoptosis occurs through activation of effector Caspases which then cleave a limited set of cellular proteins whose activation /inactivation results in the typical apoptotic morphology including membrane babbling, nuclear condensation , cell shrinkage and finally the disassembly of the cell . Survivin proteins are anti –apoptotic proteins that regulate apoptosis. BCL2 proteins are the first antiapoptotic oncoprotiens that protect the cells from a wide variety of apoptotic stimuli through interfering with apoptosis signaling in multiple way that depend on the cell type and/or the apoptotic stimulus.