Locally advanced breast cancer remains a therapeutic challenge to surgeon and oncologist. Although patients present with localized disease, they have a high incidence of distant failure and locoregional relapse if not treated appropriately. In this study 20 patients with (LABC) were treated with a combined modality strategy, from September 1999 to June 2002. 14 cases (70 %) were in stage IIIb, while 6 cases (30%) were in stage IIIa. Metastatic work up was done, and all patients were found to be free of distant metastases before neoadjuvant chemotherapy. Patients received 3 cycle of different regimens of neoadjuvant chemotherapy 14 patients received FAC, 3 patients received FEC100, 2 patients received FNC and one patient received CMF. 90% of patients had partial responses to the neoadjuvant chemotherapy (the tumor decrease more than 50% of its size), only 2 patients didn't respond to treatment. The surgical procedure was modified radical mastectomy. All patients received adjuvant treatment, radiotherapy, chemotherapy (FAC, FEC100, CMF, and FNC) and hormonal treatment, tamoxifen 20mg/ day. Follow up of patient for variable period of time ranging from12 to 24 months was performed and no patients had local recurrence, only 2 patients developed distant metastases, disease free survival was 90%. So this multimodality approach to LABC rendered most patients disease free and produced an excellent local control rate.