Background : Hypothyroidism is a prevalent disease mostly affecting middle aged women. Recently, the American Diabetes Association ADA has announced the use of glycated hemoglobin more than 6.5% for the diagnosis of diabetes mellitus. On the other hand, recent reports have stated a spuriously high level of glycated hemoglobin in non diabetic hypothyroid patients. Furthermore, conflicting results of the relation of (GA) glycated albumin (as an alternative to HbA1c) to hypothyroidism was found in several recent studies. •Objectives: Assess the HbA1c level in non diabetic hypothyroid patient and assess glycated albumin (fructosamine) as an alternative to it. Methods: 96 hypothyroid non-diabetic patients was assessed for HBA1c and fructosamine. These levels was compared to 96 controls, who are non diabetic non hypothyroid patients. Full clinical examination and history will be performed for the patients and controls.The following labs was performed for all subjects: Blood glucose level, Hemoglobin,Thyroid functions was also performed. Glycated hemoglobin (HBA1c), was done as well as fructoseamine for all candidates. •Results: HbA1c levels increases in non diabetic hypothyroid patients. There is a significant positive correlation between HbA1c and TSH. There was no significant correlation between fructosamine and thyroid function. •Conclusion: HbA1c levels increases in non diabetic hypothyroid patients. Because our study found positive correlation between fructosamine and free T4, we do not recommend it as an alternative to HbA1c for diagnosis of diabetes. Hence fasting and post prandial blood sugar are recommended for diagnosis and follow up of diabetes mellitus in hypothyroid patients.