This study is to identify the concentration of NAA, Cho and Cr containing compounds in frontal lobes, hippocampi, and thalami of patients with bipolar, which may enhance our understanding of the neurophysiology. 1H MRS was performed in 25 patients with bipolar disorder and 20 ages matched healthy subjects in the three mentioned cerebral areas and the comparable values of for NAA, Cr, and Cho have been taken and compared with patients with schizophrenia as well. The results of the study were that substantial evidence that the distribution of the metabolite alterations in the brain is significantly different in the 3 groups. Moreover, Brain metabolites are affected by number of episodes, age, age at onset, and severity of the current episode.