The current study investigated the effects of polymorphisms in interleukin (IL-10) on the natural course of hepatitis C virus (HCV) infection.This study was carried in Pediatric Hepatology Unit, Cairo University Children’s Hospital.A total of 40 anti-HCV antibody seropositive children were classified into two groups, those who were responders or non responders to HCV treatment.In the current study the relationships between polymorphisms in the gene encoding IL-10 (-1082, -592) and response to HCV treatment were studied.IL-10 gene polymorphisms (-1082, -592) were detected by real time PCR.These polymorphisms were equally distributed among the patient subgroups.This study concluded that the relationship between inherited variations in IL-10 are not associated with alterations in HCV clearance, and therefor IL-10 gene polymorphisms (-1082, -592) cannot be taken as a predictor for the response to HCV therapy.