Background Psoriasis is a chronic, inflammatory skin disease with approximate 2-3% prevalence in the general population. The etiology of psoriasis is not fully understood, but it appears to be multi-factorial, involving both genetic and environmental influences. Although the precise mechanism by which polymorphisms in IL23R influence the disease process still requires further clarification, the associations and functional evidence suggest that the IL23 pathway has a key role in the pathogenesis of psoriasis. Objective is to study the role of IL23R Arg381Gln SNP rs11209026 and other SNPs (rs2201841) of the IL23R gene in psoriasis in the Egyptian patients. Methods This study included 30 psoriatic patients and 30 normal individuals. Real time PCR was carried out for the analysis of rs11209026 SNP while PCR – RFLP was performed for the analysis of IL23R gene SNPs (rs2201841). Results Our results revealed that the (G) allele of rs11209026 (IL23R Arg381Gln) is risky while the (A) allele is protective OR 6.510 (95% CI 1. 376 - 30.792).On the other hand, genotyping of rs2201841 showed no significant difference in the 2 studied groups. Conclusion Association of IL23R Arg381Gln with psoriasis indicates that genes participating in IL23 signaling play a significant role in psoriasis pathogenesis.