Aims of the study were to find out prevalence of H. pylori in hepatic encephalopathy and to determine correlation between presence of H. pylori and severity of hepatic encephalopathy. One hundred patients (50 patients of chronic liver disease with hepatic encephalopathy and 25 cases chronic of liver disease without hepatic encephalopathy, and 25 healthy controls without any disease) were evaluated for presence of H. pylori by serology (ELISA method). Seroprevalence of H. pylori infection in the study group (patients of liver disease with hepatic encephalopathy, without hepatic encephalopathy and healthy controls without any disease) was 64% (liver disease with hepatic encephalopathy 74%, liver disease without hepatic encephalopathy 64%, and healthy control 44%). Prevalence and titre of H. pylori were found significantly increasing with the severity of hepatic encephalopathy. There is a significant association between H. pylori and patients of liver disease with hepatic encephalopathy. There may be a role of anti-H. pylori therapy in patients of hepatic encephalopathy and should be investigated further.