ART has become the frontier of infettility treatment andResearch , nowadays ART is widespread allover the world and hasBecome part of treatment modalities in infertile couples. Severalclinical advances in the field of assisted reproduction technologyhave occurred since the birth of Louise Brown such as improvementin ivulation protocols, cryopreservation in - vitro maturation , preimplantationgenetic diagnosis and have attributed to improvementin the results of treatment of infertility.