Background: Hospital acquired infections (HAIs) become an increasing worldwide problem as every year many lives are lost because of the spread of infections in hospitals. It thus become very important to review and update the epidemiology and outcome of HAI to be contrasted with community acquired infections (CAIs). Understanding these variables will help us to prioritize resources and plan strategies for decreasing the mortality and morbidity associated with each type of infection. Methods: a cross-sectional hospital based descriptive study design was done. The study included all liver, urinary system, gastro-intestinal system and prostate gland diseased patients admitted to the hospital and identified to have infection whether it was hospital acquired infection or community acquired infection during a two-year period (Jan. 2006 to Dec. 2007). Results: One hundred and twenty five patients were included in the study. They were exposed to 167 episodes of infections (108 HAIs and 59 CAIs). The most common type of HAIs was blood stream infection, while the most common type of CAIs was UTI. Patients with liver and gastro-intestinal diseases showed more HAIs than CAIs, while urinary system and prostate patients showed more CAIs than HAIs. Gram negative organisms were the most common organisms found in our study (60 %). E.coli is the most common organism involved in both Hospital and community acquired infection with a total of 22.3%.