Tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. Children with brain tumors may subsequently have deficits in neuroendocrine function a patient may have a deficiency of one hormone or any combination of hormones .The present work aimed to define the hypothalamo-hypophseal axis in patients presenting with intracranial tumors. This included cases that presented before and after treatment. A thirty cases of children suffering from brain tumors were investigated, to define the hypothalamo-hypophseal axis in patients presented with intracranial tumors, this included cases which presented pre or post-operatively.