Aim of the work: to determine the value of three-dimensional ultrasound measurement of the volumes of gestational, yolk sacs and retrochorionic blood flow study in the prediction of pregnancy outcome in the first trimester. Patients and methods: This is a prospective study which was carried out at Kasr el-Eini hospital in the period between December 2009 and June 2011. The study included 110 pregnant women in their first trimester. They were subjected to three-dimensional ultrasonographic measurement of gestational, yolk sac volumes and retrochorionic blood flow study during the first trimester. Each patient was examined once and revised after twenty weeks’gestation for the occurrence of normal or abnormal pregnancy progression. Results: The present study included 110 participants, they were divided into 2 groups of participants the first group included 50 participants (Normal-Control group), the second group included 60 participants with the same inclusion and exclusion criteria of the first group except for having history of two or more abortions in the first trimester. On Comparing data between the cases who continued pregnancy and those who did not in relation to the controls who continued the GSV showed statistically significant difference between the three groups, the YSV showed no statistically significant difference between the three groups. The RI of retrochorionic arteries showed statistically significant difference between the three groups.