Fortunately, the complications encountered after TRUS biopsy are commonly minor and self-limited, including mild hematuria, hematospermia, or transient rectal bleeding. Occasionally, the resultant morbidities may be significant enough to require surgical intervention, e.g. urinary retention (0.2-2.6%) and severe rectal bleeding (0.6%). Urinary tract infection (UTI) is considered the second most frequently noted complication of prostate biopsy, following bleeding complications. It may be described as a minor or major complication depending on its severity. Although simple, UTI frequently occurs after biopsy (1.2-11.3%), and febrile UTIs are also not uncommon (1.4–4.5%).4,5 Sepsis, one of the most serious clinical sequel, is encountered in 0.1–2.2% of cases after biopsy.6 Some reports have debated the benefit of antibiotic prophylaxis before biopsy,7 whereas other studies demonstrated an incidence of asymptomatic bacteruria and transient bacteremia after biopsies performed without antibiotic prophylaxis in 16-100% of cases 8,9,10,11