Surgical site infections are serious problem worldwide. Urosurgery department is one of the departments with high rate of infection in the hospital. However, detailed information about the incidence and risk factors of infection in the department is deficient.The general objective of the study is to decrease the incidence of surgical site infections among the urosurgical patients attending Kasr Al-Ainy hospital.The study was conducted in the urosurgery department and included 125 patients. The study was divided into two parts; analytic part including the preoperative and postoperative care of patients in order to find out the incidence and risk factors of infection and descriptive part to collect data about the structure of the department and the performance of medical care providers. The opinion of the care givers about the cause of infection in the department was elicited through focus group discussion.Results of the study showed that the incidence of postoperative urine infection amounted to 70.3 % and 34.5 % of the wounds acquired infection. Presence of chronic diseases, presence of preoperative and postoperative catheters, and the intake of chemoprophylaxis were significant risk factors for infection. Gram negative bacilli were the most common isolated pathogens from postoperative urine samples.