Hegazi, layla A., Mattar, Mirvat M., Husain, Sahar K.
Authors
Abdel-Al, Asmaa Ahmad
Accessioned
2017-03-30 06:23:32
Available
2017-03-30 06:23:32
type
M.D. Thesis
Abstract
GATA-1 and GATA-2 are 2 transcription factors act co-operatively during normal haematopoiesis. Our study aimed to detected their expression patterns in MDS and AAML. GATA-2 was detected in 69.6% of MDS cases, while GATA-1 was negative in all cases. In AML cases, GATA-1 was expressed in 56% of cases and GATA-2 in 80% of cases. Our study suggests critical role of GATA-1 and GATA-2 in the development of MDS and AML.