200 patients with diabetes mellitus and acute myocardial infarction were divided into two groups. The insulin – glucose group (100 patients), received insulin-glucose infusion for ≥ 24 hrs, followed by subcutaneous insulin every 6 hrs for 10 days, while the control group (100 patients), received standard insulin therapy. Conclusion: We concluded that insulin glucose infusion followed by multidose subcutaneous insulin significantly lowered the congestive heart failure and recurrent infarction, and improved the fractional shortening, ejection fraction and wall motion score in diabetic patients with acute myocardial infarction compared to standard insulin scale therapy during the early hospitalization period.