Ischaemia reperfusion injury causes increased morbidity during liver resection and transplantation and can precipitate primary graft non-function which is a potentially lethal complication. Modulation and assessment of ischaemia reperfusion injury are important objectives in tackling this phenomenon. The reperfusion injury cascade is a complex one, consequently, in this study the modulation of hepatic ischaemia reperfusion injury is discussed using three different interventions, at three different levels of the cascade. Its assessment is investigated using histological and ultrastructural changes, adhesion molecule expression, cytokine and transaminase release, changes in bile flow and its composition as assessed by magnetic resonance spectroscopy, haemodynamic and energetic changes as assessed by laser Doppler flowmetry and near infrared spectroscopy.