Bone development occurs either by intramembranous or intracartilagenous ossification. Endochondral derived bones grow in width by membranous ossification through appositional bone growth from the periosteum, also, membrane derived bones may undergo subsequent growth and elongation through endochondral ossification at growth plate. Growth of bone is subjected to many factors including growth factors, hormonal, dietary, local factors …. Etc. The most important of these are the growth factors which are polypeptides present in the organic bone matrix and stimulate bone growth and mineralization. Currently, many growth factors are under continuous work and trials to prepare recombinant human forms to be commercially available for clinical use. Their use in treatment of non-united fractures, spinal fusion techniques and osteoporosis will be promising in near future.