The prevalence of Computer-related musculoskeletal disorders was studied among Egyptians. The prevalence was higher in females, age above 35 years, overweight and obese, smokers, data entry operators, working for more than 6 hours per day and for more than 6 years, working in seated posture, absence of rest breaks, frequent overtime work, using no back support, highly placed monitor and keyboard, non use of copy holder, absence of control over workplace, and absence of co-worker support.