Compared to long-term dialysis maintenance, kidney transplant improves the quality of life and reduces the mortality risk for most patients with end-stage renal disease. Graft survival depends on different risk factors in the short (1 year) and long terms (5-10 years). Allograft nephropathy is considered an important cause of long term graft dysfunction. Allograft nephropathy is either de novo or due to recurrence of the original renal diseases. It is probable that as graft failure from death and acute rejection decline, the incidence of graft failure from recurrent and de novo disease will increase. Our aim is to discuss the causes, presentation, methods of diagnosis and treatment of post transplantation glomerulonephritis and address its contribution to graft dysfunction and suggest early detection and subsequently its prevention.