Introduction : enhanced oxidative stress and generation of reactive oxygen species found in liver of patients of chronic hepatitis C initiate a cascade leading to active fibrogenesis.Subjects and methods: The present study was conducted on 40 Egyptian chronic active hepatitis C infected patients (CAHC) divided into two groups: Group I(a), 26 patients of chronic active hepatitis C without cirrhosis and group I(b), 14 patients of chronic active hepatitis C with cirrhosis The patients were compared to a control group, group II of 15 healthy subjects of matching age and sex. Serum MDA (Thiobarbituric chemical method) and ceruloplasmin (Cp) (Nephlometric method) were measured for all patients and controls. Results: The mean serum levels of MDA were significantly higher in all CAHC patients (11.63 ± 3.89 ) in CAHC without cirrhosis, ( 9.3 ± 1 ) in CAHC with cirrhosis, compared to controls (8.05 ± 0.8 ) (P <0.01 ), with the highest values observed in CAHC without cirrhosis when compared to CAHC with cirrhosis. Serum MDA was positively correlated with serum ALT (r =0.663; P <0.01) but negatively correlated with serum protein ( r = -0.506; P <0.01) and negatively correlated with serum albumin ( r = -0.633; P<0.01 ). However comparison between group I (a), group I (b) and group II showed no statistically significant differences as regard serum ceruloplasmin. Conclusion: The measurement of lipid peroxidation product e.g. ( MDA) can be used for follow up of chronic active hepatitis C infected patients as it is a useful marker for disease activity and for early detection of cirrhosis.