The housefly is a major domestic pest in human population, causing various diseases such as dysentery and typhoid, and having detrimental effects on the environmental hygiene and livestock management. For this purpose laboratory bred Musca domestica larvae were subjected to organophosphorous compounds, synthetic Pyrethroids, carbamates and insect growth regulators. The present study revealed variations in the effectiveness of different insecticides and IGRs against Musca domestica larvae. Comparing effectiveness of the three larvicides and the two IGRs at the least concentration (0.001ppm), it was found that diflubenzuron with a percent mortality of 42% proved to be the most effective one (LC50= 0.002ppm). it was followed by pyriproxyfen with a percent mortality of 25% (LC50= 0.004ppm). This was followed by diazinon with a mortality of 22% (LC50=0.007ppm) and then deltamethrin with 19% mortality rate, (LC50=0.009ppm) while the least effective insecticide was chemicarb with a percent mortality of 18% (LC50= 0.011ppm). On the other hand at the highest concentration applied (0.1ppm) it was found that diflubenzuron and pyriproxyfen with a percent mortality of 100% proved to be the most effective. Other effective larvicides were diazinon with a mortality rate of 89% followed by deltamethrin achieving a 85% mortality rate and lastly chemicarb with a mortality rate of 80%.