The SLICC/ACR DI is a validated assessment tool for total organ system damage present for at least 6 months regardless of the etiology. The aim of this study was to determine the prevalence of total and individual organ damage in patients with SLE and to find the factors that are related to damage. Forty female patients, all fulfilling the ACR criteria for the diagnosis of SLE were included in this study. The results obtained were arranged to fill the items of the SLICC/ACR DI. The prevalence of total organ damage among SLE patients was 60%. The prevalence of individual organ damage was as follows: Ocular 2.5%, NPS 25%, renal 17.5%, pulmonary 7.5%, C.V. 12.5%, GIT 7.5%, MSK 17.5%, PVD 17.5%, skin 2.5%, POF 10%, D.M. 5% and no patient had malignancy. There was a highly statistically significant correlation between damage and diastolic blood pressure, SLEDAI and ESR There was a statistically significant correlation between damage and systolic B.P.. Negative correlation was found between damage and platelets counts. Statistically significant correlation between damage and daily steroid dose was found while a highly statistically significant correlation between damage and the highest steroids dose ever taken by the patient was found. There was a highly statistically significant difference between patients with damage and those without damage as regards their cardiovascular manifestations. There was a statistically significant difference between patients with damage and those without damage as regards their pulmonary and neuropsychiatric manifestations.