Objective: To estimate the prevalence of hepatitis B and hepatitis C in patients with chronic liver disease and the relation of chronic liver diseases to risk factors. With highlighting of the prevalence of Occult hepatitis B infection within our study group.Patients and methods: A retrospective study performed on 400 patients with chronic liver disease (elevated liver enzymes by 1.5 to 2 folds, and/or positivity of any of the following serum and viral markers, namely, HBsAg, PCR for HBV DNA, HCV Ab, Qualitative and/or Quantitative PCR for HCV RNA, and/or ultrasonograpic changes suggestive of chronic liver disease as portal tract thickening, coarse, shrunken, fatty changes of the liver, caudate lobe enlargement of the liver, splenomegaly, and ascites) who presented to the outpatient clinic of the Hepatology and Gastroenterology Department of the Police Authority Hospital in Agouza, Giza.Conclusion: This retrospective study was performed on 400 chronic liver disease patients. 84% had chronic hepatitis “C” and 5.2% had chronic hepatitis “B”. Males (66%) are more liable to chronic liver disease. 53% gave history of schistosomiasis and 80% of them has intravenous parenteral treatment for it ultrasound examination showed that 45% has liver cirrhosis, 47% has portal hypertension, 41% has splenomegaly, 32% has ascites, and 3.6% has hepatic focal lesions. Ten patients had occult hepatitis B. Eighteen patients had concomitant viral infection.