Obesity is a condition in which excess body fat may put a person at health risk. It is associated with increased incidence of endometrial, breast, prostate, and colon cancers. It is associated with high incidence of breast cancer among postmenopausal women only. Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death.Locally advanced primary breast cancer is a heterogeneous disease accounting for approximately 10-15% of all newly diagnosed breast cancer. Even without evidence of distant metastases at the time of diagnosis, this group of patients has a poor prognosis and limited 5-year survival. Obesity only increases the risk of breast cancer among postmenopausal women only. In this study, 50 Egyptian female patients with locally advanced breast cancer were investigated retrospectively for the pattern of presentation of locally advanced breast cancer, rate of response to chemotherapy, rate of recurrence and distant metastasis. Also, the impact of obesity on the incidence, response and recurrence after chemotherapy was investigated. Results of this study showed that Patients age ranged from 32 to 65 years. 48% (n=24) were postmenopausal. BMI ranging from 20.7 to 41.9 with a mean of 30.86. 70% (n=35) of the patients having BMI>25. As regarding the tumor size, 76%of the patients were presented with tumor size greater than 5cm (t3). While 24% were presented with tumors attached to skin or chest wall (T4). Complete clinical response with no palpable tumor was noted in 18 %( n=9), 66 %( n=33) showed partial response, and 16 %( n=8) had no response. While pathologically, complete response was found in only 8 %( n=4), partial response in 72% (n=40), and no response was found in 20% (n=6) of cases. The response to chemotherapy was the only variable significantly related to incidence of recurrence and/or metastasis was it occurs in 100% of patient who didn't respond to chemotherapy.