Background: Chronic inflammation was found to play an important role in the development of cardiovascular risk factors. Homocysteine and fibrinogen have been identified as major independent risk factors for cardiovascular disease. Lichen planus is assumed to be closely related to dyslipidemia. Several cytokines involved in lichen planus pathogenesis, could explain its association with metabolic syndrome and dyslipidemia, as chronic inflammation has been suggested as a component of the metabolic syndrome. Objective: The aim of the present study is to detect cardiovascular risk factors in a sample of Egyptian patients with lichen planus.Patients and methods: This study was done on 40 patients of lichen planus and 40 healthy controls. All patients and controls were subjected to clinical examination. Serum levels of homocysteine, fibrinogen and CRP were measured by ELISA technique. Metabolic syndrome parameters including anthropometric measures, lipid profiles, blood sugar and blood pressure were studied.Results: Patients with lichen planus showed significant association with metabolic syndrome parameters including lipid profile derangements than controls. Serum homocysteine, fibrinogen and CRP were significantly higher in lichen planus patients than controls. Serum homocysteine correlated with serum CRP and serum fibrinogen. However there was no correlation between serum levels of homocysteine and fibrinogen with metabolic syndrome criteria and related disorders. In conclusion: Patients with lichen planus are at increased risk of metabolic and cardiovascular complications.