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TET2 mutation in myeloid neoplasms

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Clinical & Chemical pathology

Advisors

Abdel-Rahman, Aesha M., Abdel-Ghany, Huda M., Rashed, Riham A.

Authors

Fawzi, Lousi Gamal

Accessioned

2017-07-12 06:39:44

Available

2017-07-12 06:39:44

type

M.Sc. Thesis

Abstract

In acute myeloid leukemia (AML), both cytogenetic and molecular abnormalities are strongly associated with prognosis. In particular, in cytogenetically normal AML.Families of myeloproliferative neoplasms (MPNs) are characterized by a clinical and genetic heterogenceity. First, within MPN families, distinct clinical entities are observed, the 3 main ones being polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).Recently, acquired mutations of the Ten-Eleven Translocation 2 gene, (TET2), were reported in approximately 12% of sporadic MPN (PV, ET, and PMF) as well as in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

Issued

1 Jan 2013

DOI

http://dx.doi.org/10.21473/iknito-space/34592

Details

Type

Thesis

Created At

28 Jan 2023