Hepatic dysfunction not only appears with chronic liver disease but in critically ill patients. It appears with some conditions like ischemic hepatitis, congestive hepatopathy, total parental nutrition, sepsis and drug hepatotoxicity. Liver function abnormalities present either as derangement of liver chemistry or overt clinical manifestations of liver disease. This problem (hepatic dysfunction) may be overlooked in the intensive care patient so; here we concentrate about the cause and predisposing factors of hepatic dysfunction in critically ill patient.