The discipline of liver transplantation has been developed over the past decades, and it is now considered the gold standard for the treatment of patients with end-stage liver disease. Increasing success rates has led to broader indications and increased number of potential recipients. The patient selected for transplant should suffer from irreversible, progressive disease for which there is no acceptable, alternative therapy. Recipients are broadly defined as having an intolerable quality of life because of liver disease or having an anticipated length of life of less than 1 year because of liver failure. Recipients are priority ranked by application of the Model of End- Stage Liver Disease (MELD) scoring system. This system ranks patients by expected mortality based on the severity of their liver disease. Candidates for liver transplantation are subjected to thorough evaluation and assessment of all body systems to figure out all possible complications of end stage liver disease as hepatorenal syndrome, hepatopulmonary syndrome and hepatic encephalopathy. Liver function is also assessed through all available laboratory and radiological methods. Finally they are subjected to routine preanesthetic evaluation.