A comparative study of the clinical maternal and fetal effects and the plasma concentrations of 0.5% extradural levobupivacaine versus racemic bupivacaine for cesarean delivery
Ahmad, Fattma A. , Aumran, Amina H. , Khalil, Muna S.
Authors
Fahim, Mirvat Muhammad Saeid
Accessioned
2017-03-30 06:20:35
Available
2017-03-30 06:20:35
type
M.D. Thesis
Abstract
Levobupivacaine was synthesized for the purpose of finding another local anaesthetic agent with the anaesthetic strength of bupivacaine but without the cardio toxic and central nervous system sequalae. This study compares the efficacy of 0.5% levobupivacaine with 0.5% bupivacaine for epidural anaesthesia in parturients undergoing elective cesarean section. Fifty healthy obstetric patients completed the study. Patients were randomized to receive 20 ml of either 0.5% levobupivacaine or 0.5% bupivacaine.The points for assessements included onset, offset and quality of anaesthesia. Blood pressure and heart rate recordings were done. Neonatal Apgar score was performed. Venous samples for pharmacokinetic analysis were obtained from both mother and fetus. The results showed levels of sensory block, motor block and overall quality of anaesthesia to be comparable between the two groups.