Negative pressure wound therapy (NPWT) has been used to promote healing of chronic wounds and pressure ulcers (decubitus ulcers) by creating controlled negative pressure over the wound that is thought to increase local vascularity and oxygenation of the wound bed, reduce edema by evacuating wound fluid, and remove exudate and bacteria. This study is a randomized control study to evaluate the efficacy of NPWT. In this study 50 patients was admitted to the hospital with diabetic foot ulcer which are chosen as stage III and IV of Wagner classification. All patients are of good limb vascularity and patients with ankle brachial index less than 0.7 are excluded. Peripheral neuritis is found in 82% of the patients. Debridement is done for all patients of the study and then the patients are classified into two groups, each 25 patients (group A and group B). Group A is managed with VAC therapy with change of the polyurethane dressing every 72 hours and a negative pressure of -0.125 mm hg is applied to the wound. The other group (B) is managed with daily dressing using moist saline dressing.