Introduction : Overt diabetes mellitus (DM) is observed in 21 to 40 % of patients with liver cirrhosis (LC). There are two ways in which DM is related to LC: firstly, type 2 diabetes mellitus (T2DM), which is often associated with metabolic syndrome, causes chronic liver disease (steatosis, steatohepatitis, and LC. Secondly, LC may cause impaired glucose tolerance (IGT) and DM.Liver is a major source of the endogenous lipoproteins in vivo, meanwhile, and it is the main site of the synthesis, storage, transport and degradation of lipid. Each protein is influenced by liver disease in a different way and serum lipoprotein concentrations with faster turn-over are more reduced with respect to those with slower turn-over Although NAFLD is a hepatic manifestation of metabolic syndrome and an association between SUA level and metabolic syndrome has been well documented, the association between NAFLD and SUA level is controversial Some studies have reported that NAFLD patients had higher SUA levels than controls (Lee et al., 2006), where as another study found that this association was not statistically significant. Aim of work1- To detect the metabolic abnormalities as regard lipid, glucose and uric acid in various degree of chronic liver disease.2-To compare metabolic abnormalities as regard lipid, glucose and uric acid in various degree of chronic liver disease.Subject and methodsThis study was carried out at (Kaser El Aini Hospital) during the period from January 2011 to June 2012 and laboratory investigations were done at National Institute of Diabetes and Endocrinology . It included 100 subjects classified into 4 groups according to clinical, laboratory investigation and abdominal ultrasound. Group I : 25 chronic active hepatits patients.Group II : 25 compensated liver cirrhosis patients.Group III :25 decompensated liver cirrhosis patients.Group IV : Control group 25 subjects.Verbal consent was taken and all patients are age related.Methods : All patients included in this study subjected to the following : 1- Full history taking2- Clinical examination :General examination, Chest and heart examination Abdominal examination : shrunken liver , splenomegaly, ascites.3- Investigations Abdominal ultrasound, lipid profile, Fasting blood sugar , Serum uric acid, Serum albumin, Liver enzymes , Prothrombin time , concentration , INR and Serum creatinine .Conclusion1-There are glucose abnormalities including (DM and IGT) in various degrees of chronic liver disease.2- Lipid profile (Total cholesterol, HDL and LDL) but not TG are decreased in relation to severity of liver disease.3- Uric acid level decreased in decompensated liver cirrhosis and increased in chronic active hepatitis.