Childhood obesity is one of the most serious public health challenges of the 21st century. Particular attention has been directed to the potential role of sleep duration as an obesity risk in children. Sleep restriction leads to increased levels of ghrelin from the stomach which stimulates appetite. This work aimed to study the association between sleep duration and subsequent obesity in children and adolescents and to study relation between duration of sleep and level of ghrlein and insulin hormones. The present study was carried out on fifty children and adolescents with simple exogenous obesity as well as twenty healthy subjects, age and sex matched, as a control group. Both patient and control groups were subjected to history taking , sleep sheet fulfillment , clinical assessment including ( weight, height,waist circumference , hip circumference ) , laboratory investigations ( serum blood ghrelin , lipid profile ,fasting blood glucose as well as serum insulin ). Results The number of sleep hours were significantly less and the interupption of sleep duration was highly significant more among the obese group compared to control group .The serum ghrelin increased among obese group as compared to control group. The obese patients had increase in insulin level and HOMA-IR level as indicator of insulin resistance level compared to control group.The mean serum triglycerides level was higher among the obese group compared to control group . Finally there was female predominance in obese patients: Male to female ratio was ( 1:1.6).In conclusion, obese patients in the current study showed short interrupted sleep patterns which led to increased level of ghrelin hormone and subsequently increased appetite leading to obesity, insulin resistance and increase in serum level of triglycerides .