Background and Objectives: Low intensity laser therapy (LILT) have been increasingly used in periodontal therapy. Studies suggest that LILT is able to stimulate soft tissue and hard tissue healing. The aim of this clinical trial was to evaluate the efficacy of coronally positioned flap (CAF) combined with low intensity laser therapy (LILT) compared to coronally positioned flap alone in the management of Class II furcation involvement by clinical and radio densito-metric analysis. Subjects and methods: All ten systemically healthy patients who were included in the study were assigned in a split mouth design clinical trial to receive (CAF) on class II furcation defects. One side received LILT while the other side did not. A diode laser with a wavelength of 850nm-980nm was used and energy output of 2W/ min was applied after CAF. Defects received 12 sessions of LILT carried out on 3 alternative days, one week after surgery (3 sessions per day), in each session, laser was applied for five minutes, with interval time of 30 minutes between successive sessions. Plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), tooth mobility, gingival margin level (GR), furcation horizontal probing depth (HPD) and width of keratinized gingiva (WKG) were recorded at baseline, 1, and 6 months after treatment. Radio densito-metric analysis was done for both sides at baseline and 6 months. Results: The LILT defects showed significantly more improvement in probing pocket depth (PPD) at the end of the study period between both groups. LILT defect sites showed significant more improvement in the gingival index (GI) level compared to the control sites at 1 month, while no significant difference was noted between the two groups at baseline, and 6 month. As per the clinical attachment level (CAL), no significant difference between the groups at baseline, but a significant difference was noted at six month. A highly significant difference was observed in the gingival margin level (GR) and furcation horizontal probing depth (HPD) in the laser group at the end of the study period, while in the control group significant difference was found. Width of keratinized gingiva (WKG) showed a highly significant change between baseline and 6 months in laser group while no significant change was noticed for the control group. Concerning the plaque index (PI) there was no significant difference noticed between the two groups. Analysis of bone density showed a mean increase of bone density of 67Hu in the laser group, while the density for the CAF group decreased by a mean of 59.5 Hu, thus significant difference was reported between both groups. Conclusion: The results of this study revealed a non-significant statistical difference on the effect of group on percentage changes of PI, GI PPD and GR between coronally advanced flap alone and diode laser used as an adjunct. However, significant difference on the effect of group on percentage change in CAL, WKG, furcation HPD as well as bone density were reported