The present study was conducted to characterize clinically and radiographically the effect of using Platelet Rich Fibrin (PRF) autologous graft in enhancing the augmentation results of palatal autogenous bone blocks. Materials and Method: Twelve patients (7 females and 5 males) with fourteen sites that suffered from horizontal alveolar bone defects in the anterior maxillary ridge (ridge width ≥ 4.5 mm) with one or two missing teeth space were augmented with autogenous palatal bone blocks 4 months prior to implant placement. PRF was used to cover the block in the test group while the block was solely used in the control. Bone width was measured with a manual caliper preaugmentation, at 0 and 4 months. Cone Beam Computed Tomography (CBCT) scans were performed preaugmentation procedure and after 4 months of augmentation prior to implant placement. Results: All the autografts of the test group integrated successfully while one graft from the control group failed after 4 months. On re-entry the PRF group showed less mean bone resorption (MBR) than the control group. (MBR PRF: 0.763mm ±0.150 “21.59%”, MBR control: 1.607mm ±0.235 “39.96 %”, p= 0.003). No statistical significant difference in the grey scale (bone density) voxel value of the CBCT between both groups. (Mean grey scale voxel units PRF group: 861.43 ± 62.47, Mean grey scale voxel units control group: 698.67 ± 67.85 , p = 0.05) Conclusions: Palatal block autograft resorption rate is significantly decreased by the use of PRF membrane coverage although no improvement in bone density was observed.