This study was performed to investigate role of periodontal salivary biomarker in success rate of implant, Dentium two piece implants were placed 20 patients with teeth indicated for extraction in the area of maxillary anterior and premolar teeth. All patients were free from systemic diseases and non-smokers. Before extraction, saliva sample is taken from the mouth, then the teeth were extracted after raising a mucoperiosteal flap or flapless following an atruamatic approach and the implants were placed immediately in the fresh extraction sockets, then a series of clinical measurement were obtained. This study was conducted to make correlate the presence of salivary interleukin 1- α & 6 and matrix metalloproteinases (MMP-8) to the state of functioning implant, clinically and radiographically. The follow up clinics and radio graphical and laboratory salivary biomarkers was done after implantation every month for a year for any signs of implantitis clinically including gingival index and bleeding on probing and Plaque index and mobility and radiographically. And a whole saliva sample was taken for each patient at rest every month for a year , saliva subjected to lab investigation of interleukin 1α & 6 and matrix metalloproteinases (MMP-8) comparing between cases showing clinical and radiographic indication of implantitis with normal cases as control . In this study the patient show a good healing over the implant site and no complications were noticed during the clinical follow up period. The results were assessed clinically and radiographically. Radiographic evaluation. There was no statistically significant difference between cases. And different biomarkers (IL-1 α , IL-6 and MMP-8) and clinical parameters regarding gingival index and plaque index at 1-6 months and 9 month, there was no statistically significant correlation between Different biomarkers and clinical parameters. And there was a statistically significant positive correlation between GI and PI i.e. an increase in GI is associated with an increase in PI. After 7 month, there was an increase in GI is associated with a decrease in IL-1 α and there was a negative correlation between them. At 8 month, there was an increase in IL-1 α is associated with an increase in MMP-8 and there was a positive correlation between them. At 9 month, there was an increase in IL-6 is associated with a decrease in MMP-8. At 10 month, there was an increase in IL-6 is associated with a decrease in MMP-8 and increase in IL- 6 with a decrease in GI and there was a negative correlation between them. At 11 month, there was an increase in IL-6 is associated with a decrease in MMP-8 and increase in IL-6 with a decrease in GI and there was a negative correlation between them. At 12 month, there was an increase in IL-1 α is associated with a decrease in PI and there was a negative correlation between them. Based on the results obtained for the current study, it could be noted the role of different periodontal salivary biomarker are aids detection of implant success rate, and no complications were noticed during the clinical follow up period.