Chronic periodontitis is one of the most common infectious diseases of the oral cavity largely associated with the imbalance of indigenous microflora resulting in overgrowth of periodontal pathogens such as Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans. According to the American Academy of Periodontology, The goals of periodontal therapy are to preserve the natural dentition, Periodontium and peri-implant tissues; to maintain and improve periodontal and peri-implant health, comfort, esthetics, and function. Currently accepted clinical signs of a healthy periodontium include the absence of inflammatory signs of disease. Subjects and Methods: The present study was conducted on fifteen (male & female).patients participants with moderate chronic periodontitis (Armitage, 1999) were enrolled in this clinical study. The clinical trial was carried out as a randomized, split mouth design. It compared the clinical parameters response to two different treatment protocols (scaling and root planning with locally delivered tetracycline presteron; TCPS and scaling and root planning alone) at different time points; baseline, after 12-weeks. The oral cavity of each patient was divided into two halves; right and left. Each half received scaling and root planning with or without locally delivered tetracycline presteron; TCPS application. Results: The reduction of PPD in the test group from base line to 3 months which decreased from (4.0 to 1.27 mm). CAL gain from base line to 3 months (4.11 to 1.4mm).While in the control group the reduction of PPD from baseline to 3 months which decreased from (3.94 to 1.62) .CAL gain from baseline to 3 months (4.05 to 1.73). The percentage reduction in PPD and CAL after 3 months therapy in the test group was the highest while SRP alone (control group) showed the lowest results. Conclusion: The use of locally delivered tetracycline presteron (TCPS) as adjunctive to SRP is relatively new addition in management of moderate periodontitis.Tetracycline presteron (TCPS) resulted in the gain of clinical attachment level and reduction in probing pocket depth after 3 months follow up period; accordingly local drug delivery system used in the present study is safe and effective treatment modality for chronic periodontitis.