Aim of the study: evaluation of the effect of implant direction and superstructure material on micro-strain distribution around single-tooth implant supported crowns. Materials and methods: 20 endoessous root form implants were inserted in epoxy resin rectangular models and divided into two groups (n=10); group I: straight implant received straight zirconia abutments, group II: inclined implant (17° buccally) received angled zirconia abutments. Each group was subdivided into two subgroups according to the superstructure material; subgroup A: received all-ceramic crowns and subgroup B: received fiber reinforced composite (FRC) crowns. Strain gauges were attached to each epoxy model and samples were subjected to 250 N load and readings were recorded and used to calculate the principal stresses and strains. Results: Angled implants with all-ceramic crowns showed the statistically significantly highest means tensile micro-strains. This was followed by angled implants with FRC crowns. Straight implants with FRC crowns showed statistically significantly lower mean compressive micro-strains than straight implants with all-ceramic crowns which showed the statistically significantly lowest mean compressive micro-strains. Conclusion: Implant direction and superstructure material significantly affect micro-strains around implants. The placement of implants along the direction of axial loading of the proposed prosthesis may promote better stress/strain distribution.