The aim of this study was to evaluate the effect of the application of acidulated phosphate fluoride gel and bleaching agent on the surface roughness and color change of Zirconia Incoris TZI, IPS e.max press, Lava™ Ultimate Restorative and VITA ENAMIC ceramic materials. Materials and methods: 40 discs were constructed from four ceramic materials (N=40). The 40 discs were divided into four main groups (N =10 per each group) : Group I: zirconia InCoris TZI; group II : Vita Enamic; group III : Lava™ Ultimate Restorative; group VI : IPS e.max press. Each group was further subdivided into 2 subgroups according to the treatment applied : subgroup A: acidulated phosphate fluoride gel was applied on the surface of 5 samples and subgroup B : bleaching agent was applied on the surface of 5 samples. 1.23% acidulated phosphate fluoride gel was applied on Subgroup A for 8 minutes treatment, which is equivalent to 1 year of treatment clinically. While 30% hydrogen peroxide in-office bleaching agent was applied on subgroup B for 45 minutes (3 cycles), 15 minutes for each cycle, according to the manufacturer’s instructions. Surface roughness of all samples was measured before and after different treatments using a profilometer and a random selected sample from each group was scanned by Scanning Electron microscope (SEM).Color change (ΔE) was assessed following different treatments using a spectrophotometer. All samples were measured twice; before samples treatment (control) and following application of either 1.23% APF or in-office bleaching agent with 30% hydrogen peroxide. Then the data were collected, tabulated and then statistically analyzed using two- way ANOVA and pair wise Bonferroni’s post-hoc test(P<0.05). Results: Zirconia Incoris TZI and IPS Emax Press showed better color stability than hybrid ceramics; Lava Ultimate and Vita Enamic after application of two different treatments, bleaching showed perceivable color change (ΔE) than fluoride application in all tested ceramic materials, both treatments applied had adversely affected the surface texture of all tested ceramic materials except lava ultimate material. Conclusion: clinicians should consider replacement of such restorative materials after bleaching and fluoride application.