Statement of the problem: Implant supported restorations transfer occlusal forces to the peri-implant bone and excessive force may jeopardize the osseointegration and the success of the implant. Superstructure material may affect stresses around endosseous implants. Considering hybrid ceramic superstructures having low elastic modulus close to that of natural teeth may help reducing the amount of these stresses transferred to the implant.Purpose: The aim of this study was to evaluate the microstrain around endosseous implant with hybrid ceramic superstructure compared to porcelain fused to metal one.Materials and Methods: Sixteen root form endosseous tapered implants were inserted in epoxy resin blocks. According to the superstructure material the sixteen implants were divided into two main groups: Group I: (n=8) implants received cement retained hybrid ceramic (Enamic) superstructures fabricated by CAD/CAM technology. Group II: (n=8) implants received cement retained porcelain fused to metal superstructures fabricated by conventional casting of the metal framework and porcelain veneering. All superstructures were constructed resembling upper first premolars following standardized protocols. The epoxy resin models were prepared to receive strain gauges around the implant surfaces where four strain gauges were used for each specimen on the mesial, buccal, distal and palatal surfaces of the epoxy model. A computerized universal testing machine was used to apply a static load of 300N, at a rate of 1 mm/min. The load was applied progressively starting from zero to 300 N during which readings from the strain meter were recorded on the computer.Results: It was found that At the mesial surface, implants restored with Vita Enamic superstructures showed statistically significantly (P ≤ 0.05) lower mean microstrains than those restored with PFM ones (339 ± 194.3) and (451.9 ± 214.4) respectively. Whereas, at the buccal, distal and palatal surfaces there were no statistically significant difference between the two groups.Conclusions: The superstructure material of implant supported prosthesis, whether Porcelain Fused to Metal (PFM) or VITA ENAMIC, had no effect on the microstrains generated around dental endosseous implants.