Epilepsy belongs to the most prevalent neurological disorders in pediatric patients. About 30% of the patients are refractory to conventional anti-epileptic drugs and many experience side effects such as sedation and cognitive impairment. The majority of patients suffer from complex partial seizures, which have been shown to originate in many cases in the mesial temporal lobe structures, particularly in the hippocampal-amygdaloid region. Neuroimaging is an essential diagnostic tool for evaluating new- onset seizure disorders and chronic uncontrolled epilepsy. Recent advances in neuroimaging have enhanced the clinician’s ability to identify the underlying causes of seizure disorders in many patients; thus, the appropriate medical or surgical therapy can be used. Intractable pediatric epilepsy patients represent a challenging clinical population, although advances in neuroimaging continue to improve diagnosis and treatment in these patients. Patients with medically uncontrolled partial seizures are possible candidates for surgery so the seizure focus must be correctly lateralized. Electroencephalography EEG, video EEG, structural and metabolic imaging are used for lateralization. Our study has shown that multimodality neuroimaging plays an essential role in noninvasively localizing epileptogenic foci for possible surgical resection.