Hepatic focal lesions may be benign or malignant. They require accurate diagnosis, which relies on appropriate imaging and image-guided biopsy. Diffusion weighted MRI in the liver is a relative new and increasingly used technique. It can be obtained during a single breath-hold, there is no need to use contrast media and it provides information that reflects tissue cellularity and organization. ADC maps can provide quantitative measurements of tissue water diffusivity. It proved to be helpful in the characterization of hepatic focal lesions.